5/30/2025
Last update
5/30/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 16 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
8
We investigated how long-term exposure to urban air pollution affects the recovery from ischemic stroke in mice. Our findings showed that breathing in fine particulate matter increases neuroinflammation and cardiac injury, leading to higher mortality rates after a stroke.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Read More
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Read More
8
We examined various studies comparing tocotrienol and tocopherol, types of vitamin E, in managing atherosclerotic cardiovascular disease. After reviewing 516 articles, we found that tocotrienol significantly reduced cholesterol and inflammatory markers, showing promising benefits for heart health. In contrast, tocopherol presented mixed results, sometimes increasing mortality risk. This suggests that tocotrienol may be a safer and more effective choice for improving cardiovascular health.
Read More
Most Useful Reviews
9
Aging prevention
22 people found this helpful
Vitamin E prolongs youth and beauty as it contains multiple tocopherols, with α-tocopherol being the most active. This powerful antioxidant stabilises cell membranes and interacts with vitamin C. Supplementing with tocopherols, such as those from NOW Foods, helps maintain health and appearance while preventing cardiovascular disease.
Read More
9
Immunity boost
5 people found this helpful
I take vitamin E-400 from NOW Foods, recommended by my doctor. It is a natural vitamin that combines four tocopherols and is well absorbed. Vitamin E is an excellent antioxidant that helps prevent cardiovascular disease, lowers “bad” LDL cholesterol, and enhances tissue respiration while boosting immunity.
Read More
9
Age-related disease
2 people found this helpful
Vitamin E is a crucial fat-soluble vitamin with strong antioxidant properties that prevent lipid oxidation. It helps to reduce the risks of arteriosclerosis and blood clots, lower blood pressure and LDL cholesterol, and maintain cell health, making it an essential supplement for preventing age-related cardiovascular disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
- All Researches
8
Antioxidants reduce CVD mortality risk
We investigated the connection between dietary antioxidants, including vitamin E, and mortality risks in patients with cardiovascular disease (CVD). In our research with 1,395 participants, we found that higher levels of antioxidants were linked to decreased all-cause and cardiovascular-cause deaths.
Specifically, vitamins like C and E showed beneficial effects. This suggests that boosting our antioxidant intake could be a helpful strategy for improving health outcomes in those with CVD.
Specifically, vitamins like C and E showed beneficial effects. This suggests that boosting our antioxidant intake could be a helpful strategy for improving health outcomes in those with CVD.
Read More
8
We investigated how long-term exposure to urban air pollution affects the recovery from ischemic stroke in mice. Our findings showed that breathing in fine particulate matter increases neuroinflammation and cardiac injury, leading to higher mortality rates after a stroke.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Interestingly, incorporating a vitamin E-rich diet helped reduce cardiac damage and lung inflammation caused by this exposure. We saw a noteworthy improvement in survival rates among mice with ischemic strokes who received the vitamin E, highlighting its potential protective effects against the dangers of urban air pollution.
Read More
8
Higher vitamin E linked to decreased mortality
In this extensive study of over 16,000 adults with hypertension, we found that higher dietary antioxidant intake, including vitamin E, is linked to a reduced risk of deaths from all causes and specifically from cardiovascular disease (CVD).
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
Read More
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Read More
8
We examined various studies comparing tocotrienol and tocopherol, types of vitamin E, in managing atherosclerotic cardiovascular disease. After reviewing 516 articles, we found that tocotrienol significantly reduced cholesterol and inflammatory markers, showing promising benefits for heart health. In contrast, tocopherol presented mixed results, sometimes increasing mortality risk. This suggests that tocotrienol may be a safer and more effective choice for improving cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Aging prevention
22 people found this helpful
Vitamin E prolongs youth and beauty as it contains multiple tocopherols, with α-tocopherol being the most active. This powerful antioxidant stabilises cell membranes and interacts with vitamin C. Supplementing with tocopherols, such as those from NOW Foods, helps maintain health and appearance while preventing cardiovascular disease.
Read More
9
Immunity boost
5 people found this helpful
I take vitamin E-400 from NOW Foods, recommended by my doctor. It is a natural vitamin that combines four tocopherols and is well absorbed. Vitamin E is an excellent antioxidant that helps prevent cardiovascular disease, lowers “bad” LDL cholesterol, and enhances tissue respiration while boosting immunity.
Read More
9
Age-related disease
2 people found this helpful
Vitamin E is a crucial fat-soluble vitamin with strong antioxidant properties that prevent lipid oxidation. It helps to reduce the risks of arteriosclerosis and blood clots, lower blood pressure and LDL cholesterol, and maintain cell health, making it an essential supplement for preventing age-related cardiovascular disease.
Read More
7.5
Immunity improvement
24 people found this helpful
Vitamin E is essential for pregnant women and is a powerful antioxidant. It benefits men by increasing androgen levels and supporting muscle growth. Low levels can elevate the risk of diseases, including impaired immunity and cardiovascular disease. A daily intake of at least 50 IU is recommended to achieve useful levels of 30 µmol/L.
Read More
7.5
Heart health
10 people found this helpful
This quality supplement has natural vitamin E with mixed tocopherols and organic olive oil for better absorption. Vitamin E is beneficial for heart health, skin, diabetes, and overall wellbeing, while deficiencies can heighten the risk of conditions such as cardiovascular disease. The soft capsules are small and easy to consume.
Read More
Frequently Asked Questions
7.5
Daily vitality
1 people found this helpful
NOW Foods E-400 with Mixed Tocopherols has significantly enhanced my daily health routine. Beyond improving hair and skin, it alleviates discomfort and enhances blood circulation, which contributes positively to my overall health and helps in mitigating cardiovascular disease.
7.5
Oxidation prevention
3 people found this helpful
Vitamin E acts as a powerful antioxidant, preventing excessive cell oxidation and protecting cardiovascular health. It lowers blood pressure and triglycerides while preventing platelet coagulation and vessel adhesion, thus aiding in maintaining healthy blood vessels.
7.5
Pain relief
2 people found this helpful
Since taking vitamin E, my menstrual pain has eased significantly, improving my overall comfort. The capsules are small and easy to swallow.
9
Immunity boost
5 people found this helpful
I take vitamin E-400 from NOW Foods, recommended by my doctor. It is a natural vitamin that combines four tocopherols and is well absorbed. Vitamin E is an excellent antioxidant that helps prevent cardiovascular disease, lowers “bad” LDL cholesterol, and enhances tissue respiration while boosting immunity.
9
Aging prevention
22 people found this helpful
Vitamin E prolongs youth and beauty as it contains multiple tocopherols, with α-tocopherol being the most active. This powerful antioxidant stabilises cell membranes and interacts with vitamin C. Supplementing with tocopherols, such as those from NOW Foods, helps maintain health and appearance while preventing cardiovascular disease.
7.5
Inflammation reduction
1 people found this helpful
All tocopherols are antioxidants that may help reduce inflammation and promote heart health. Vitamin E can support immune function and eye health. However, excessive intake may lead to blood thinning and affect clotting, so I recommend taking breaks every few days.
7.5
Immunity improvement
24 people found this helpful
Vitamin E is essential for pregnant women and is a powerful antioxidant. It benefits men by increasing androgen levels and supporting muscle growth. Low levels can elevate the risk of diseases, including impaired immunity and cardiovascular disease. A daily intake of at least 50 IU is recommended to achieve useful levels of 30 µmol/L.
8
Vitamin E intake and heart health
We investigated how dietary vitamin E intake relates to cardiovascular disease and mortality using data from over 39,000 participants in the NHANES study from 2003 to 2018.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
Our findings showed that people with higher vitamin E consumption had a significantly lower risk of developing cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E were associated with a 43% lower odds of cardiovascular issues compared to those with lower intakes. Yet, results for cardiovascular-related deaths showed less certainty.
This suggests that including vitamin E-rich foods in our diets could have positive effects on heart health and longevity.
8
Higher vitamin E linked to decreased mortality
In this extensive study of over 16,000 adults with hypertension, we found that higher dietary antioxidant intake, including vitamin E, is linked to a reduced risk of deaths from all causes and specifically from cardiovascular disease (CVD).
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
Over about seven years of following participants, those with the highest levels of vitamin E intake showed a lower likelihood of CVD mortality compared to those with lower intakes.
While these findings are promising, further research is still needed to solidify these conclusions.
2
We explored how certain antioxidants, especially vitamin E (α-tocopherol), relate to cardiovascular disease risk using a two-sample Mendelian randomization approach.
Surprisingly, our findings suggest that higher levels of α-tocopherol might be associated with an increased risk of serious heart conditions like myocardial infarction and arrhythmias.
Similarly, retinol was linked to greater risks for cardiomyopathy and heart failure. This challenges the common perception of antioxidants as solely beneficial, indicating that some may actually pose health risks.
More research is needed to fully understand these relationships and their implications for our dietary choices.
Surprisingly, our findings suggest that higher levels of α-tocopherol might be associated with an increased risk of serious heart conditions like myocardial infarction and arrhythmias.
Similarly, retinol was linked to greater risks for cardiomyopathy and heart failure. This challenges the common perception of antioxidants as solely beneficial, indicating that some may actually pose health risks.
More research is needed to fully understand these relationships and their implications for our dietary choices.
7
We explored how a six-week high-antioxidant-capacity diet affects patients with cardiovascular disease. This experimental study included 48 participants, and we measured various health markers, like oxidative stress and inflammation, before and after the dietary intervention.
Our findings showed that the diet significantly shifted antioxidant levels and reduced inflammatory markers, particularly interleukin-6. Although individual results depended on each person's initial antioxidant capacity, the overall trend suggested a reduction in oxidative stress.
Unfortunately, this study did not yield a clear significant benefit regarding cardiovascular outcomes, indicating that more research is needed in this area.
Our findings showed that the diet significantly shifted antioxidant levels and reduced inflammatory markers, particularly interleukin-6. Although individual results depended on each person's initial antioxidant capacity, the overall trend suggested a reduction in oxidative stress.
Unfortunately, this study did not yield a clear significant benefit regarding cardiovascular outcomes, indicating that more research is needed in this area.
7
We looked at how vitamins E, B6, and B12 relate to coronary heart disease (CHD) using data from over 33,000 people collected between 2003 and 2020.
Our analysis suggested that Vitamin E and B6 may help protect against CHD, especially in women and individuals who smoke or have a higher body mass index. However, Vitamin B12 showed minimal connection to heart disease.
Overall, while Vitamin E and B6 demonstrate potential benefits, the impact of lifestyle factors like income and education can't be overlooked.
Our analysis suggested that Vitamin E and B6 may help protect against CHD, especially in women and individuals who smoke or have a higher body mass index. However, Vitamin B12 showed minimal connection to heart disease.
Overall, while Vitamin E and B6 demonstrate potential benefits, the impact of lifestyle factors like income and education can't be overlooked.
References
- Hu X, Zhao Z, An Q, Li Y, Wang B. Association of independent dietary antioxidant intake, and CDAI level with risks of all-cause and cardiovascular-cause death among population with cardiovascular disease. BMC Public Health. 2025;25:1327. 10.1186/s12889-025-22481-1
- Yang R, Lv M, Yang X, Zhai S. A Mendelian randomized study of circulating antioxidants in the diet and risk of cardiovascular disease. Sci Rep. 2025;15:10341. 10.1038/s41598-025-94369-4
- Czlapka-Matyasik M, Wadolowska L, Gut P, Gramza-Michałowska A. Changes in Oxidative Stress, Inflammatory Markers, and Lipid Profile After a 6-Week High-Antioxidant-Capacity Dietary Intervention in CVD Patients. Nutrients. 2025;17. 10.3390/nu17050806
- Ishihara N, Tanaka M, Namba K, Kawano S, Nishimura S, et al. Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice. J Toxicol Sci. 2025;50:147. 10.2131/jts.50.147
- Zhao S, Cao Y, Liu H, Liu A. Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study. Nutr J. 2025;24:14. 10.1186/s12937-024-01062-9
- Zeng Q, Liao M, Li Y, She F, Zhang P. Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data. Int J Cardiol Cardiovasc Risk Prev. 2025;24:200340. 10.1016/j.ijcrp.2024.200340
- Ren W, Li Y, Lu C, Liu S, Shao Y, et al. Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999-2018. Food Funct. 2024;15:10037. 10.1039/d4fo02893g
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. 10.1038/s41598-024-68413-8
- Wang Y, Han L, Ling S, Sha Y, Sun H. Dietary intake of potassium, vitamin E, and vitamin C emerges as the most significant predictors of cardiovascular disease risk in adults. Medicine (Baltimore). 2024;103:e39180. 10.1097/MD.0000000000039180
- Rafique S, Khan DA, Farhat K, Khan MA, Noor M, et al. Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans. J Pak Med Assoc. 2024;74:1124. 10.47391/JPMA.9227
- Sun Y, Zhang H, Qi G, Tian W. Nutrient deficiency patterns and all-cause and cardiovascular mortality in older adults with hypertension: a latent class analysis. BMC Public Health. 2024;24:1551. 10.1186/s12889-024-19003-w
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Yakoubi S. Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies. IUBMB Life. 2024;76:666. 10.1002/iub.2819
- Liu C, Liang D. Association between Dietary Vitamin E Intake and the Risk of Hypertension in US Adults. Curr Vasc Pharmacol. 2024;22:391. 10.2174/0115701611297956240425115501
